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The first test showed that the half‑life of hydroxybupropion was considerably longer in 8 subjects with alcoholic liver disease than in 8 healthy volunteers (32 ± 14 hours versus 21 ± 5 hrs, specifically).

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It is not typically expected to induce negative impacts in breastfed infants; nonetheless, there are case reports of feasible seizure in partly breastfed 6-month-olds.